Lineage Commitment of Dermal Fibroblast Progenitors Is Controlled by Kdm6b-Mediated Chromatin Demethylation

    August 2023 in “ The EMBO Journal ”
    Quan M Phan, Lucia Salz, Sam S Kindl, Jayden S Lopez, Sean Thompson, Jasson Makkar, Iwona M. Driskell, Ryan R. Driskell
    TLDR Kdm6b is crucial for skin cell differentiation.
    The study investigates the epigenetic mechanisms controlling the differentiation of Dermal Fibroblast Progenitors (DFPs) into distinct fibroblast lineages during skin development. It was found that DFPs have a repressive chromatin profile, marked by H3K27me3, which limits their ability to reform skin in allograft assays. The research highlights the role of the H3K27me3 demethylase, Kdm6b/Jmjd3, in modulating chromatin derepression. Deleting Kdm6b/Jmjd3 in mice led to the loss of adipocyte compartments and inhibited dermal papilla functions. The study provides insights into the differentiation process of DFPs and introduces a new multiomics search tool.
    Discuss this study in the Community →

    Research cited in this study

    21 / 21 results

    Related Community Posts Join

    6 / 1000+ results

      community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

       128 upvotes 7 years ago
      Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

      community Comprehensive Microneedling Guide

      in Microneedling  287 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Occipitalis Muscle Tension Theory

      in Treatment  8 upvotes 2 weeks ago
      Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community What’s the consensus on The Ordinary multipeptide hair serum?

      in Treatment  10 upvotes 3 years ago
      The Ordinary multipeptide hair serum is used alongside treatments like minoxidil, topical finasteride, and derma rolling, with some users reporting hair thickening and vellus hair regrowth. However, experiences vary, and some users are skeptical due to the lack of solid evidence and mixed efficacy reports.

    Similar Research

    5 / 1000+ results