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GlossaryH3K27me3

chemical modification on histone H3 that represses gene expression

H3K27me3 stands for trimethylation of the 27th lysine residue on histone H3, a protein around which DNA is wrapped. This specific chemical modification is associated with the repression of gene expression, meaning it can turn off certain genes. In the context of hair and alopecia, changes in H3K27me3 levels can influence the activity of genes involved in hair growth and loss.

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Research

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research EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

354 citations , February 2011 in “Genes & Development”

EZH1 and EZH2 are crucial for healthy hair growth and skin repair.

research Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

191 citations , September 2011 in “Cell stem cell”

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

research Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling

19 citations , September 2019 in “PLOS genetics”

Telomere damage affects skin and hair follicle stem cells by messing up important growth signals.

research Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation

10 citations , August 2023 in “The EMBO Journal”

Kdm6b is crucial for skin cell differentiation.

research Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration

6 citations , December 2021 in “PLoS Genetics”

Polycomb Repressive Complex 2 is not needed for hair regeneration.

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Community Join

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community Expectations control for SCUBE3

in Research/Science 20 upvotes 2 years ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

community Scientists discover hair growth signaling molecule SCUBE3 as potential baldness cure- 🧐

in Research/Science 17 upvotes 3 years ago

Scientists discover SCUBE3 molecule for potential baldness cure. Mice used in research for hair growth signaling.

community KX826 New Phase 3 Trial In China for 2025: 1.0% concentration

in Research/Science 60 upvotes 1 year ago

KX-826 is undergoing Phase III trials in China as a potential treatment for male pattern baldness, with some users considering it as an alternative or addition to finasteride and dutasteride. Opinions on its effectiveness vary, with some users reporting positive results and others finding it expensive and ineffective.

community Mystery compound found to be safe and effective at treating hair loss. Details in comments.

in Technology 4 upvotes 7 years ago

A compound called MTP3 from the Monoterpene family was found to be safe and highly effective at treating hair loss by inhibiting the FGF5 gene, but its identity is undisclosed for commercial reasons. No specific treatments like Minoxidil, finasteride, or RU58841 were discussed.

community KX-826 Phase 3 Failed. Sorry guys...

in Research/Science 50 upvotes 2 years ago

The conversation discusses the failure of Phase 3 trials for the hair loss treatment KX-826, with no significant difference found between the drug and placebo. Some users express disappointment and skepticism, while others discuss alternative treatments like Minoxidil, finasteride, and RU58841.

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