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GlossaryKeratinization

process where skin cells produce keratin and become tough

Keratinization, also known as cornification, is the biological process by which keratin, a protective protein, is produced and accumulated in cells of the epidermis, the outermost layer of the skin. This process results in the formation of a tough, protective layer of dead cells that helps to prevent water loss and protect against environmental damage, pathogens, and physical abrasion.

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research Keratinization and Its Disorders

95 citations , September 2012 in “Oman Medical Journal”

Mutations in keratin genes can cause skin and mucosa disorders.

research Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin

94 citations , October 1994 in “The Journal of Cell Biology”

Too much keratin 16 in mice skin causes abnormal skin thickening and structure.

research Patterns of Epithelial Expression of Fos Protein Suggest Important Role in the Transition from Viable to Cornified Cell During Keratinization

83 citations , February 1991 in “Development”

Fos protein is crucial for cell transition to cornification in keratinized tissues.

research Structural and Immunocytochemical Characterization of Keratinization in Vertebrate Epidermis and Epidermal Derivatives

82 citations , January 2006 in “International review of cytology”

Vertebrate skin evolved to be more specialized and complex, especially in land animals.

research The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids

73 citations , January 2016 in “International review of cell and molecular biology”

Cornification evolved from keratinization in vertebrates, with differences between mammals and sauropsids.

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community Blaming Finasteride doesn't help you solve anything: dry eyes

in Finasteride/Dutasteride 52 upvotes 11 months ago

Finasteride is debated for causing dry eyes, with some users experiencing relief after stopping it, while others find no connection. Topical treatments like dutasteride and minoxidil are suggested as alternatives, with advice to consult medical professionals.