Evaluation of Lactic Acid Ferment Lysate for the Management of Oily Skin: Impact on Sebum, Hydration, and Microbiota

This study evaluated the effects of a topical cream containing 3% lactic acid ferment lysate VHProbi ® MixP on oily skin over a 60-day period with 42 participants. Results showed significant reductions in sebum production (31.44%), porphyrin levels (44.60%), and pore size (25.03%), alongside improvements in skin hydration (63.68%) and texture (38.43%). Additionally, the cream altered the facial microbiota, increasing α-diversity and shifting bacterial composition, notably reducing Staphylococcus spp. and Cutibacterium spp. while increasing Streptococcus spp. The findings suggest that VHProbi ® MixP may be effective in managing oily skin by reducing hyperseborrhea, enhancing hydration, and modulating the skin's microbial community.