Treatment of Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective, Real-Life Analysis in a Tertiary Center in Germany

This retrospective study at a German tertiary center evaluated 110 patients with Lichen Planopilaris (LPP) and Frontal Fibrosing Alopecia (FFA). It found that topical treatments were largely ineffective, with only 14% achieving stable disease. Systemic treatments, particularly hydroxychloroquine and cyclosporine A, showed significant improvement in symptoms, with response rates of 62% and 71%, respectively. However, discontinuation often led to symptom exacerbation, highlighting the need for ongoing treatment. Adverse events caused treatment cessation in 17-22% of cases. The study suggests that sustained systemic treatment is beneficial, and Janus kinase inhibitors may be effective as second-line treatments.