Lineage Identity and Location Within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin

September 2018 in “ Journal of Investigative Dermatology ”

Ana Korosec, Sophie Frech, Bernhard Geßlbauer, Martin Vierhapper, Christine Radtke, Peter Petzelbauer, Beate M. Lichtenberger

fibroblasts papillary fibroblasts reticular fibroblasts FAP CD90 adipogenic differentiation dermis cell surface markers

TLDR Papillary and reticular fibroblasts have distinct roles and are influenced by their environment.

The study identified two cell surface markers, FAP and CD90, that distinguished between papillary and reticular fibroblasts in human skin. FAP + CD90 – cells, associated with papillary fibroblasts, showed increased proliferative potential and specific expression profiles, while FAP – CD90 + cells, linked to reticular fibroblasts, exhibited high levels of certain markers and underwent adipogenic differentiation. These findings confirmed the distinct lineages and functions of fibroblasts in the dermis, although their distribution was not strictly confined to specific dermal layers, suggesting that the microenvironment influenced their function.

View this study on jidonline.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

225 citations , April 2018 in “Journal of Investigative Dermatology”

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

research Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

418 citations , January 2018 in “Journal of Investigative Dermatology”

Researchers found four distinct fibroblast types in human skin, which could help in treating wounds and fibrotic diseases.

research In Vitro Models to Study Hair Follicle Generation

5 citations , November 2017 in “Elsevier eBooks”

Scientists can now grow hair-like structures in a lab using special 3D culture systems, which could potentially help people with hair loss or severe burns.

research Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins

33 citations , September 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

Human hair follicle dermal cells can effectively replace other cells in engineered skin.

research Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages

115 citations , February 2016 in “Nature Communications”

Epidermal β-catenin activation changes the dermis by signaling different fibroblast types.

research Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

87 citations , January 2016 in “Development”

Blocking β-catenin in skin cells improves hair growth during wound healing.

research Defining Dermal Adipose Tissue

218 citations , May 2014 in “Experimental Dermatology”

Skin fat cells help with skin balance, hair growth, and healing wounds.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

Two fibroblast types shape skin structure and repair differently.

Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

research Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth

256 citations , October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Growing human skin cells in a 3D environment can stimulate new hair growth.