TLDR Loose anagen hair syndrome may be caused by keratin gene mutations.
The study explored whether Loose Anagen Hair Syndrome (LAHS) was a keratin disorder by examining 17 patients, with molecular analyses on 9 patients and their families. It identified a mutation, E337K, in the K6HF keratin gene in 3 families, suggesting a possible link to LAHS and a dominant inheritance pattern with variable penetrance. However, the study did not conclusively link LAHS to keratin mutations, indicating that other genetic factors might be involved. It also noted associated conditions like hypodontia and atopic dermatitis, and suggested that defects in the inner root sheath or companion layer could affect hair anchorage. The study highlighted the need for further research to fully understand the genetic basis of LAHS.
The user discusses their experience with diffuse unpatterned alopecia and acquired progressive hair kinkering, noting improvements with treatments including biotin, pantothenic acid, finasteride, ketoconazole, and zinc pyrithione shampoo. They report thicker, healthier hair and improved scalp condition, attributing success mainly to biotin, pantothenic acid, and finasteride.
Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.
The conversation discusses various theories of hair loss, including DHT sensitivity and genetic factors, with the user willing to use themselves for research due to having a hair loss gene but different hair loss patterns compared to their brothers. Specific treatments were not mentioned in the provided text.
The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.
A potential non-invasive topical treatment targeting the WNT Signaling Pathway for hair regeneration is being researched, with positive results on human hair follicle cells. Current effective treatments for hair loss include Minoxidil, finasteride, and hair transplantation.
