Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes?

The review explores the potential of using liposomes to enhance the skin permeation of the antiaging compound GHK–Cu, which naturally struggles to penetrate the skin's barrier. Liposomes, due to their biocompatibility, could improve the delivery and efficacy of GHK–Cu. However, there is a significant research gap in studying the permeation of liposome-encapsulated GHK–Cu, as most studies focus on its free form. The review emphasizes the need for methodological advancements to better assess the effectiveness of liposomal carriers. Various methods for measuring skin permeation are discussed, with the Strat-M® synthetic membrane noted for its reliability. Encapsulation in ionic liquids has shown promise in enhancing skin penetration. Despite advancements, understanding the skin permeation of GHK–Cu-liposome systems remains a research gap, and improved methodologies are needed to study these interactions with human skin.