Protective Effects of a New Human Placental Extract Against Hair Graying and Chemotherapy-Induced Peripheral Neuropathy

    May 2026 in “ International Journal of Molecular Sciences ”
    Eri Horio, Yasuhiro Katahira, Natsuki Yamaguchi, Miki Igarashi, Hideaki Hasegawa, Satomi Miyakawa, Shota Toda, Izuru Mizoguchi, Ning Qu, Hiromitsu Anamizu, Shinichiro Ikeda, Hirohiko Matsumoto, Takayuki Yoshimoto
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    TLDR The new human placental extract may help prevent hair graying and reduce nerve pain from chemotherapy.
    The study investigates a new human placental extract (HPE) formulated under milder conditions to preserve bioactive proteins, including thioredoxin-1 and extracellular matrix proteins. This HPE demonstrated antioxidant and neurite outgrowth activities in neuronal cells and effectively reduced hair graying in mice caused by X-ray irradiation. It also alleviated chemotherapy-induced peripheral neuropathy in mice, restoring nerve function and reducing pain sensitivity. The study involved multiple experiments with 5 mice per group. The findings suggest that HPE could be a promising therapy for hair graying and neuropathy, though further research is needed to confirm the roles of specific proteins and ensure its efficacy and safety.
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