Protective Effects of a New Human Placental Extract Against Hair Graying and Chemotherapy-Induced Peripheral Neuropathy

    May 2026 in “ International Journal of Molecular Sciences ”
    Eri Horio, Yasuhiro Katahira, Natsuki Yamaguchi, Miki Igarashi, Hideaki Hasegawa, Satomi Miyakawa, Shota Toda, Izuru Mizoguchi, Ning Qu, Hiromitsu Anamizu, Shinichiro Ikeda, Hirohiko Matsumoto, Takayuki Yoshimoto
    TLDR The new human placental extract may help prevent hair graying and reduce nerve pain from chemotherapy.
    This study explores a new formulation of human placental extract (HPE) prepared without acid hydrolysis and autoclaving, which retains high-molecular-weight proteins like thioredoxin-1 and thrombospondin-1. The new HPE demonstrated antioxidant and neurite outgrowth activities in neuronal cells. In a mouse model, it significantly reduced hair graying caused by X-ray irradiation and alleviated mechanical allodynia in chemotherapy-induced peripheral neuropathy. The ability to produce HPE non-invasively and in large quantities suggests its potential as an effective therapy through multiple mechanisms.
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