A Novel Crosslinking Approach for Biomanufacturing of a Collagen-Based Skin Dermal Template

    December 2024 in “ Macromolecular Bioscience ”
    Weng Wan Chan, Kaushik Roy, Bach Quang Le, Hariharan Ezhilarasu, Xiaoqian Zhang, Ryan G. Lim, Avinanda Banerjee, Moni Abraham Kuriakose, Kimmie Ng, Priya Murugan, Chun Ting Goh, Weibiao Zhou, May Win Naing, Srikala Raghavan, Deepak Choudhury
    TLDR The new collagen template speeds up production and supports skin healing without harmful reactions.
    This study introduces a novel crosslinking process for collagen-based skin dermal templates, using UV irradiation followed by glutaraldehyde (GA) crosslinking, which reduces the crosslinking time from 48 to 24 hours compared to traditional methods. The new collagen sponge template supports better proliferation of human dermal fibroblast cells and shows similar regeneration of full-thickness skin wounds in mouse models compared to the commercial Integra template. Importantly, the sponge template does not trigger abnormal angiogenic or immune responses, suggesting it as a promising alternative for collagen sponge scaffold production in treating third-degree burns.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 712 results

      community Comprehensive Microneedling Guide

      in Microneedling  289 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community It's crazy how it's 2018 and the only hair loss treatments we have feature undesirable side effects and/or aren't even effective for many people.

       131 upvotes 7 years ago
      Hair loss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hair loss treatments despite decades of research.

      community It’s getting worse. (4 months)

      in Update  203 upvotes 2 years ago
      The conversation discusses hair loss treatments, with users suggesting the use of finasteride daily, considering minoxidil for aggressive hair loss, and discussing the normalcy of shedding during treatment. Some users recommend adding Nizoral shampoo and switching to dutasteride for better results.

      community Vitamin C and hair growth PH levels

      in Product  32 upvotes 4 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community Do we have to be junkies? That's funny

      in Research/Science  13 upvotes 1 year ago
      The conversation discusses using finasteride, dutasteride, minoxidil, cialis, and metformin to protect hair and health. Some users caution against self-prescribing these drugs due to potential risks and complications.

    Similar Research

    5 / 1000+ results