A Brief Report on PCOS and Its Inducing Model

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting 8-9% of women of reproductive age, leading to hyperandrogenism, infertility, abnormal follicular maturation, and anovulation. The condition is characterized by the production of immature or partially mature eggs that form ovarian cysts, resulting in enlarged ovaries that secrete excessive androgens. This hormonal imbalance causes symptoms such as abnormal weight gain, irregular menstrual cycles, hair loss, and infertility. The pathogenesis of PCOS is not fully understood, but experimental animal models using dehydroepiandrosterone (DHEA) and 5αdihydrotestosterone (DHT) are valuable for studying the mechanisms of its onset and progression.