Modern Polycystic Ovary Syndrome Management: Intelligent Drug Delivery and Metabolic Reprogramming for Ovarian Restoration and Fertility Optimization

    April 2026 in “ Biomolecules ”
    Abdel Halim Harrath, Maroua Jalouli, Mohammed Al‐Zharani, Md Ataur Rahman
    TLDR New treatments for PCOS using smart drug delivery, metabolic changes, and AI show promise but need more research.
    The document reviews advancements in managing Polycystic Ovary Syndrome (PCOS), focusing on intelligent drug delivery, metabolic reprogramming, and AI-driven precision medicine to restore ovarian function and optimize fertility. It highlights the potential of nanoparticle-based drug delivery systems, metabolic therapies like metformin and inositols, and lifestyle interventions such as ketogenic diets. The use of AI in diagnosing and treating PCOS is also explored, emphasizing personalized medicine. While these approaches show promise, the document stresses the need for larger, long-term studies to validate these strategies and improve clinical outcomes for PCOS patients.
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