The PCOS Phenotypes in Unselected Populations (P-PUP) Study: Participant Clinical Features and Data Harmonization on Analysis of Individual Participant Data

    July 2025 in “ BMC Medicine ”
    Asmamaw Demis, Sylvia Kiconco, Arul Earnest, Mahnaz Bahri Khomami, Raja Ram Dhungana, Ricardo Azziz, Л. В. Сутурина, Xiaomiao Zhao, Alessandra Gambineri, Fahimeh Ramezani Tehrani, Bulent O. Yildiz, Jinju Kim, Liangzhi Xu, Christian Chigozie Makwe, Helena Teede, Anju E. Joham, Chau Thien Tay
    TLDR PCOS affects 11% of women, highlighting the need for standardized diagnosis.
    The P-PUP study analyzed data from 9,979 women across eight countries to assess the prevalence and phenotypes of polycystic ovary syndrome (PCOS) in unselected populations. It highlighted significant variability in data collection and diagnostic criteria, focusing on ovulatory dysfunction, hyperandrogenism, and polycystic ovary morphology. The study successfully harmonized data according to international guidelines, revealing an overall PCOS prevalence of 11.0%. The findings underscore the need for standardized data collection and diagnostic criteria to improve accuracy and consistency in diagnosing PCOS, aiming to enhance future research and treatment strategies.
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