Novel Placenta-Derived Liquid Product Suitable for Cosmetic Application Produced by Fermentation and Digestion of Porcine or Equine Placenta Using Lactic Acid Bacterium Enterococcus Faecalis PR31

    January 2024 in “ Fermentation ”
    Kanako Matsunaga, Yasuhiko Komatsu
    TLDR The new placenta-derived liquid improves skin moisture better than traditional extracts.
    The study developed a novel placenta-derived liquid product for cosmetic use by fermenting porcine and equine placentas with the lactic acid bacterium Enterococcus faecalis PR31. The resulting placenta ferment filtrates significantly stimulated the proliferation of human dermal fibroblasts and epidermal keratinocytes, outperforming traditional placental extracts. The filtrates demonstrated superior moisturizing properties, maintaining high stratum corneum water content for up to 6 hours post-application. Metabolome analysis identified molecules like lactic acid and pyruvic acid as contributors to these effects. A small human trial with five female volunteers showed potential benefits for cosmetic use, suggesting promising applications for these placenta ferment filtrates in cosmetics.
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