Evolution and Mechanistic Insights of Platelet-Derived Products in Temporomandibular Joint Regeneration

This review explores the potential of autologous platelet-derived products (APDs) like platelet-rich plasma and platelet-rich fibrin in regenerating the temporomandibular joint (TMJ), which has limited natural healing ability due to its fibrocartilaginous structure and poor vascularization. Unlike traditional treatments that focus on symptom relief, APDs mimic natural healing by enhancing mesenchymal stem cell proliferation, promoting chondrogenic differentiation, and reducing inflammation through immunomodulatory pathways. The review also highlights the importance of rheological properties for clinical applications and discusses the translational aspects of using APDs for temporomandibular disorders (TMDs).