Polynucleotides High Purification Technology: A Real-World Prospective Study in a Hospital Outpatient Setting Supports PN HPT as a Regenerative Medicine Option for Acne Scar Management

This prospective cohort study evaluated the effectiveness of Polynucleotides High Purification Technology (PN HPT) combined with hyaluronic acid in treating moderate-to-severe atrophic post-acne scars in a real-world outpatient setting. Conducted with 30 participants aged 20 to 60, the study found a significant reduction in scar area and improvement in Goodman-Baron scores, with a mean scar area decrease from 106.6 to 93.1 and a 22.12% decline in Goodman-Baron scores at six months post-treatment. However, 30% of subjects did not show improvement in the Goodman-Baron classification. The study supports the clinical benefit of this regenerative approach, confirming previous controlled trial results.