Development and Characterization of Polymeric Nanoparticles Loaded with Clindamycin Phosphate for Topical Treatment of Acne Vulgaris

This study focused on developing and characterizing polymeric nanoparticles loaded with clindamycin phosphate (CDM) for the topical treatment of acne vulgaris. Two types of nanoparticles were created using chitosan and hyaluronic acid, which had opposite charges. The nanoparticles were designed to improve drug encapsulation and target drug release to pilosebaceous units. The NP-QS-CDM-3 and NP-AH-CDM-4 nanoparticles showed similar drug release profiles, but NP-AH-CDM-4 demonstrated better penetration into hair follicles, even under conditions simulating sebaceous obstruction. Both nanoparticle systems were found to be non-irritating to the skin, with NP-AH-CDM-4 showing particular promise for effective topical acne treatment.