Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives

The document compares polynucleotide (PN) and polydeoxyribonucleotide (PDRN) in dermatology, emphasizing their distinct molecular mechanisms and clinical applications. PN, with longer DNA fragments, is used for skin hydration and structural support, often in combination with hyaluronic acid. PDRN, with shorter fragments, activates adenosine A2A receptors, promoting skin fibroblast proliferation, wound healing, and anti-inflammatory effects. It shows potential in hair regeneration, improving hair thickness and density, though clinical data are limited. Both compounds are noted for their safety and efficacy, but the lack of standardized definitions poses challenges. The review calls for further research to clarify their properties and enhance their application in dermatology.