Premature Gray Hair Development in the Interbrow Region Due to Loss of Maxillary First Molars in Young Mice

February 2024 in “ Genes to Cells ”

Masae Furukawa, Haruna Yokoi, Jingshu Wang, Yoriko Ikuyo, Hirobumi Tada, Mitsuyoshi Yamada, Yosuke Shikama, Kenji Matsushita

premature hair graying tyrosinase-related protein-2 TRP-2 trigeminal nerve mRNA

TLDR Losing molars in young mice causes premature gray hair between the eyebrows.

This study investigated the effect of tooth loss on premature hair graying by extracting maxillary first molars from young mice and observing them for 3 months. The results showed that mice with extracted molars developed gray hair in the interbrow region, unlike the control group. The expression of tyrosinase-related protein-2 (TRP-2) mRNA was lower in the interbrow tissues of mice without maxillary molars, suggesting that reduced mastication and weakened trigeminal nerve input may cause premature graying. The study recommends prompt prosthetic treatment after molar loss to prevent this condition.

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Premature Gray Hair Development in the Interbrow Region Due to Loss of Maxillary First Molars in Young Mice

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