Effects of Supplementation with Two Probiotic Strains on Metabolic Profile, Hormonal Status, Oxidative Stress, and Quality of Life in Women with Polycystic Ovary Syndrome: A Study Protocol for a Randomized Clinical Trial

This study protocol outlines a randomized clinical trial investigating the effects of supplementation with two probiotic strains on women with polycystic ovary syndrome (PCOS). The trial aims to assess whether probiotics can improve hormonal, metabolic, inflammatory, and antioxidant markers in these individuals compared to a placebo group. The hypothesis is based on evidence that elevated insulin levels and gut microbiota imbalances contribute to PCOS, and that gut dysbiosis is linked to sex hormone levels and estrous cycles. The study seeks to explore the potential benefits of probiotics in addressing these issues in women with PCOS.