Effects of Supplementation with Two Probiotic Strains (Lactobacillus Helveticus and Bifidobacterium Longum) on Hormonal Status, Oxidative Stress, and Clinical Symptoms in Women with Polycystic Ovary Syndrome: A Randomized Clinical Trial

    November 2025 in “ Nutrition Journal ”
    Mahsa Shirani, Mohammad Bagherniya, Omid Sadeghi, Hatav Ghasemi Tehrani, Mohammad Hadi Eskandari, Manoj Sharma, Gholamreza Askari
    TLDR Probiotic supplements may help reduce inflammation and oxidative stress in women with PCOS.
    This randomized clinical trial involved 90 women with polycystic ovary syndrome (PCOS) and examined the effects of an 8-week supplementation with probiotics Lactobacillus helveticus and Bifidobacterium longum. The study found significant improvements in the intervention group, including increased sex hormone binding globulin, total antioxidant capacity, and superoxide dismutase activity, along with decreased free androgen index, C-reactive protein, and malondialdehyde levels, compared to the placebo group. However, changes in testosterone levels and clinical symptoms such as acne, alopecia, and hirsutism were not statistically significant. The findings suggest that probiotic supplementation may help alleviate oxidative stress, modulate hormonal factors, and reduce inflammation in women with PCOS.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 8 results

      community Thoughts on Lactobacillus Reuteri 6475?

      in Treatment  4 upvotes 11 months ago
      Lactobacillus reuteri 6475 is being used by a person who reports healthier hair after one month, despite initial shedding. The discussion includes speculation about its effects on gut bacteria and scalp inflammation.

      community Pattern hair loss could be due to gut bacteria

       51 upvotes 6 years ago
      Feeding bacteria-free mice with Lactobacillus murinus worsened hair loss, but a regular diet with biotin stopped it. The conversation suggests gut bacteria and diet may influence hair loss, with some skepticism and discussion about other factors like DHT and genetics.

      community My Experience and a Discourse on "DUPA"

      in Treatment  9 upvotes 1 year ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

      community How uninformed the general public is about hair loss

      in Chat  315 upvotes 2 years ago
      The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

    Similar Research

    5 / 347 results