Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis

    January 2024 in “ Journal of Investigative Dermatology ”
    Yi‐Kai Hong, Daw‐Yang Hwang, Chao‐Chun Yang, Siao Muk Cheng, Peng‐Chieh Chen, Wilson Aala, Hans I‐Chen Harn, S. Evans, Alexandros Onoufriadis, S R Liu, Yu‐Chen Lin, Yi‐Han Chang, Tzu‐Kun Lo, Kuo‐Shu Hung, Yi‐Chao Lee, Ming‐Jer Tang, Kurt Q. Lu, John A. McGrath, Chao‐Kai Hsu
    TLDR Corticosteroids can reduce scarring in acne keloidalis by targeting specific cells.
    The study explores the role of SPP1+ macrophages and POSTN+ fibroblasts in the fibrotic scarring of acne keloidalis (AK), a type of scarring alopecia. Using advanced RNA sequencing on scalp biopsy specimens from 4 patients, the researchers identified these cell types as key contributors to fibrosis through SPP1 signaling networks. The study found that corticosteroids can reverse the gene expression of these cells, reducing inflammation and fibrosis, and leading to clinical improvement in AK lesions. These findings provide insights into the pathobiology of AK and suggest potential therapeutic targets for managing fibrotic skin disorders.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results