Proteomic Analysis of Crimped and Straight Wool in Chinese Tan Sheep

October 2024 in “ Animals ”

An Shi, Sijia Ma, Zhuo Yang, Wei Ding, Jinyang Tian, Xin Chen, Jinzhong Tao

TLDR Crimped wool has proteins linked to crimp formation, while straight wool has proteins linked to fiber fineness, which can improve wool quality and value.

The study investigates the transition from crimped to straight wool in Tan sheep after 35 days, which affects its commercial value. Using tandem mass tag-based quantification, researchers identified 1,218 proteins, including 50 keratins and 10 keratin-associated proteins, with 213 differentially expressed proteins between crimped and straight wool. Crimped wool had higher levels of KAP24-1, K84, K32, K82, and IRDC, while straight wool had higher levels of K6A, K27, K80, KAP16-1, KAP27-1, and TCHH. The expression of KAP16-1, KAP24-1, and KAP27-1 was linked to wool crimp formation, and high expressions of TCHH, K27, and K6A in the inner root sheath were associated with fiber fineness in straight wool. These insights could help improve wool quality and its economic potential in the textile industry.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

19 / 19 results

research Study on the Expression Patterns of Inner Root Sheath-Specific Genes in Tan Sheep Hair Follicle During Different Developmental Stages

July 2024 in “Gene”

IRS-specific genes in Tan sheep hair follicles peak at birth and may affect wool crimp.

research Ovine KRT81 Variants and Their Influence on Selected Wool Traits of Commercial Value

4 citations , May 2024 in “Genes”

KRT81 gene variations in sheep affect wool weight but not fiber length or thickness.

research Spatiotemporal Expression and Haplotypes Identification of KRT84 Gene and Their Association with Wool Traits in Gansu Alpine Fine-Wool Sheep

February 2024 in “Genes”

The KRT84 gene is linked to better wool quality in Gansu Alpine Fine-wool sheep.

research Correlation Analysis of Four KRTAP Gene Polymorphisms and Cashmere Fiber Diameters in Two Cashmere Goat Breeds

September 2022 in “Canadian journal of animal science”

Certain gene variations are linked to the thickness of cashmere goat hair.

research Identification of the Key Proteins Associated With Different Hair Types in Sheep and Goats

2 citations , September 2022 in “Frontiers in genetics”

Different proteins are linked to the varying thickness of sheep and goat hair types.

research Identification of the KAP27-1 Gene in Sheep and Its Effect on Wool Traits

July 2022 in “New Zealand journal of agricultural research”

The KRTAP27-1 gene variations in sheep may affect wool length and weight.

research Wool Fiber Curvature Is Correlated With Abundance of K38 and Specific Keratin-Associated Proteins

3 citations , December 2021 in “Proteins”

Wool fiber curliness is linked to the presence of certain proteins and K38.

research The Biology And Genetics Of Curly Hair

65 citations , March 2017 in “Experimental Dermatology”

Curly hair is influenced by specific genetic variations.

research Screening and Expression of Keratin EST in Xinji Fine Wool Sheep

1 citations , January 2015 in “China Animal Husbandry & Veterinary Medicine”

Four keratin genes are crucial for hair growth in Xinji fine wool sheep.

research Identification and Sequence Analysis of the Keratin-Associated Protein 24-1 (KAP24-1) Gene Homologue in Sheep

51 citations , September 2012 in “Gene”

The research identified a gene in sheep important for wool quality, which could help improve wool traits.

research An Updated Nomenclature for Keratin-Associated Proteins

92 citations , January 2012 in “International Journal of Biological Sciences”

The document introduced a new naming system for keratin-associated proteins to improve clarity and communication across species.

research Expression Patterns of Keratin Intermediate Filament and Keratin Associated Protein Genes in Wool Follicles

95 citations , March 2009 in “Differentiation”

Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.

research Characterizing Wool Keratin

69 citations , January 2009 in “Advances in Materials Science and Engineering”

Wool keratin is reactive, biocompatible, biodegradable, and can model keratin from other sources.

research Molecular Elements of the Regulatory Control of Keratin Filament Modulator AHF/Trichohyalin in the Hair Follicle

7 citations , July 2008 in “Experimental Dermatology”

The study concluded that a protein important for hair strength is regulated by certain molecular processes and is affected by growth phases.

research Keratin Expression Provides Novel Insight Into the Morphogenesis and Function of the Companion Layer in Hair Follicles

38 citations , December 2006 in “Journal of Investigative Dermatology”

Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.

research Biology of the Wool Follicle: An Excursion into a Unique Tissue Interaction System Waiting to Be Rediscovered

117 citations , November 2006 in “Experimental Dermatology”

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle

93 citations , July 2006 in “Journal of Investigative Dermatology”

K25, K27, and K28 are found in all inner root sheath layers of hair, while K26 is only in the cuticle.

research Trichohyalin Mechanically Strengthens the Hair Follicle

108 citations , October 2003 in “Journal of biological chemistry/The Journal of biological chemistry”

Trichohyalin makes hair follicles stronger.

research Regulation of Keratin Gene Expression in Hair Follicle Differentiation

98 citations , December 1991 in “Annals of the New York Academy of Sciences”

Keratin gene regulation is similar across mammals, affecting hair follicle differentiation.