Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices

April 2026 in “ International Journal of Molecular Sciences ”

Tamara Tuma Odeh, Dillen A. Patel, Pradhyumna Mayur Pradeep, Jaiden A. Patel, Rahul Mittal, Khemraj Hirani

diabetes mellitus skin aging alopecia advanced glycation end products oxidative stress platelet-rich plasma mesenchymal stromal cell-derived products regenerative therapies cosmetic dermatology diabetes skin rejuvenation PRP

TLDR Diabetic patients need tailored cosmetic treatments for skin aging, with new therapies showing promise.

Diabetes mellitus affects 589 million adults globally, with up to 70% experiencing skin issues, including accelerated aging and alopecia, which impact quality of life. This review highlights the need for evidence-based cosmetic dermatology practices for diabetic patients, as their skin aging is driven by unique mechanisms like advanced glycation end products and oxidative stress. While demand for aesthetic procedures in this group is rising, guidance is limited. Emerging regenerative therapies, such as platelet-rich plasma and mesenchymal stromal cell-derived products, show promise for skin rejuvenation. A diabetes-informed approach is crucial for safe and effective cosmetic interventions.

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