Effectiveness Of Regenerative Medicine For Skin Lightening And Rejuvenation: A Systematic Review Of Extracellular Vesicles And Conditioned Media

This systematic review analyzed 19 studies involving 624 participants to evaluate the effectiveness of extracellular vesicles (EVs) and conditioned media (CM) for skin lightening and rejuvenation. The findings indicate significant improvements in skin elasticity, hydration, and pigmentation reduction, with EVs showing particularly promising results. For example, Lactobacillus plantarum-derived EVs increased skin elasticity by 27.07% and hydration by 21.40% over 4 weeks, while human adipose tissue stem cell-derived exosomes significantly reduced melanin levels. No severe adverse effects were reported, suggesting that EVs and CMs could be effective non-invasive treatments for skin rejuvenation. However, further research is needed to standardize these therapies and fully understand their efficacy and mechanisms.