Effectiveness Of Regenerative Medicine For Skin Lightening And Rejuvenation: A Systematic Review Of Extracellular Vesicles And Conditioned Media

September 2025 in “ Stem Cell Research & Therapy ”

Alireza Jafarzadeh, Seyed Soheil Hoseini, Elham Behrangi, Masoumeh Roohaninasab, Azadeh Goodarzi

extracellular vesicles conditioned media skin rejuvenation skin lightening

TLDR EVs and CMs may safely improve skin lightening and rejuvenation, but more research is needed.

Extracellular vesicles (EVs) and conditioned media (CMs) show promise as safe and potentially effective treatments for skin rejuvenation and lightening. Despite these positive indications, there is a need for further high-quality research to confirm their long-term safety, explore how efficacy may vary depending on the cell sources, and refine application techniques for clinical use.

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Semantic ratio: 80%