Beyond Comfortable: A Removable Antibacterial Electroconductive Cellulose Nonwoven Dressing for Accelerated Wound Healing
December 2025
in “
Nano Letters
”
tannin-modified cellulose-polypyrrole nonwoven dressing TA/Cell@PPy tannic acid antimicrobial protection electrotherapy S. aureus E. coli conductive polypyrrole endogenous electric fields re-epithelialization granulation tissue collagen matrix organization angiogenesis biomimetic nanofibrous architecture biocompatibility secondary trauma infection control tissue regeneration antibacterial dressing conductive dressing wound healing dressing antimicrobial dressing electric field therapy bacterial infection control wound closure tissue repair
TLDR The new dressing speeds up wound healing by fighting bacteria and boosting natural electric fields.
The study introduces a novel wound dressing, TA/Cell@PPy, which integrates tannic acid (TA) and polypyrrole (PPy) into cellulose nonwoven fabrics to enhance wound healing. This dressing offers antimicrobial action through rapid TA release and enhanced electrical conductivity via PPy, promoting cell migration and re-epithelialization. It demonstrates excellent cytocompatibility, hemocompatibility, and significant antibacterial efficacy against pathogens like E. coli and S. aureus. In vivo tests on Sprague–Dawley rats showed that TA/Cell@PPy significantly accelerates wound healing compared to traditional dressings, with improved re-epithelialization, granulation tissue maturation, collagen deposition, and angiogenesis. Its nonadherent design ensures trauma-free removal, making it a promising solution for complex wound management.
