November 2025 in “Advanced Healthcare Materials” Bioprinting is improving skin models for better testing of skin diseases without using animals.
September 2004 in “Experimental Dermatology” The model effectively studies how sensory nerves interact with skin components, aiding research on wound healing and hair growth.
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October 2023 in “Science Advances” 3D bioprinting can now create skin with hair-like structures for medical use.
This review discusses the challenges of skin repair, which often results in fibrotic scarring rather than true regeneration, leading to loss of function and structure. Advances in transcriptomic profiling have revealed complex gene-regulatory programs that influence healing outcomes, highlighting the roles of keratinocytes, fibroblasts, and immune cells. RNA-mediated networks, including miRNAs and lncRNAs, are crucial in processes like epithelial migration and inflammation resolution, with their dysregulation leading to scarring. Stem cell-derived skin organoids and engineered skin models offer promising experimental platforms for regenerative strategies. The review integrates findings from human and murine studies to propose a framework for regenerative skin repair, emphasizing the need for further research before clinical application.
New bio-ink can print complex tissues and organs.