Deciphering the Role of Keloid Fibroblasts in Itch

Keloid fibroblasts contribute to the itch and pain associated with keloid scars by releasing three times more histamine than normal skin fibroblasts. This histamine binds to the histamine receptor (HRH1) on sensory neurons, which is upregulated in active keloids, potentially activating these neurons. The study used fast scan cyclic voltammetry and single-cell analysis to demonstrate this mechanism, suggesting that keloid fibroblasts play a significant role in keloid pathogenesis beyond collagen deposition.