The SAHA Syndrome

January 2014

Christos C. Zouboulis, Clio Dessinioti

SAHA syndrome seborrhea acne hirsutism androgenetic alopecia peripheral hyperandrogenism polycystic ovary syndrome PCOS

TLDR SAHA syndrome links oily skin, acne, excess hair, and hair loss in women, similar to PCOS.

The SAHA syndrome, identified in 1982, described the association of seborrhea and acne with hirsutism and/or androgenetic alopecia in women, highlighting signs of peripheral hyperandrogenism in young females. It shared clinical characteristics with polycystic ovary syndrome (PCOS).

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Research cited in this study

8 / 8 results

research Acne-Associated Syndromes: Models for Better Understanding of Acne Pathogenesis

99 citations , December 2010 in “Journal of The European Academy of Dermatology and Venereology”

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

research New Developments in Our Understanding of Acne Pathogenesis and Treatment

466 citations , June 2009 in “Experimental dermatology”

We now understand more about what causes acne and this could lead to better, more personalized treatments.

research Hormones and the Pilosebaceous Unit

97 citations , March 2009 in “Dermato-endocrinology”

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

research The Clinical Evaluation of Hirsutism

67 citations , September 2008 in “Dermatologic therapy”

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

research Diagnosis and Management of the Dermatologic Manifestations of Polycystic Ovary Syndrome

97 citations , July 2006 in “Dermatologic therapy”

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

research Acne and Sebaceous Gland Function

463 citations , September 2004 in “Clinics in dermatology”

Effective acne treatments should reduce sebum, bacteria, and inflammation, with isotretinoin being the best for severe cases.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.

research The SAHA Syndrome: Overview and Classification

70 citations , January 2000 in “Hormone Research in Paediatrics”

SAHA syndrome is a condition in women involving skin and hair issues, often related to hormonal imbalances, and is treated based on the underlying cause.