TLDR New methods can detect finasteride's major urinary metabolite in urine for up to 49 hours.
The study developed and validated a sensitive method for detecting carboxy-finasteride, the major urinary metabolite of finasteride, using LC–MS and LC–MS/MS, achieving a limit of detection of 2 ng/mL. This method addressed challenges in doping control, as finasteride is used as a masking agent, and demonstrated good precision and accuracy. It was successfully applied to urine samples from a male volunteer, showing carboxy-finasteride elimination peaked at 10 hours post-administration. The method met WADA requirements and was suitable for routine analysis to detect finasteride misuse in sports.
22 citations
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July 2010 in “Drug Testing and Analysis” A quick method was developed to detect banned substances in urine for doping control.
39 citations
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April 2007 in “Therapeutic Drug Monitoring” Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.
12 citations
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June 2006 in “British Journal of Sports Medicine” Doping in football faces legal challenges with testosterone limits, hair loss treatments, and recreational drug use.
49 citations
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December 2017 in “Journal of pharmaceutical and biomedical analysis” The method effectively detects banned substances in urine for sports antidoping.
39 citations
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April 2007 in “Therapeutic Drug Monitoring” Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.
2 citations
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December 2013 in “Xenobiotica” Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.
13 citations
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November 2014 in “Toxicology Letters” Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.
22 citations
,
July 2010 in “Drug Testing and Analysis” A quick method was developed to detect banned substances in urine for doping control.
