TLDR Combining shikimic acid and Prunus mume extract may effectively treat acne naturally.
The study highlights the potential of combining shikimic acid with Prunus mume fruit extract to effectively modulate type I 5α-reductase activity, which is linked to acne. The combination, tested in vitro, showed enhanced efficacy in reducing 5α-reductase levels under testosterone-induced stress, outperforming shikimic acid alone and common acne treatments like salicylic and azelaic acids. The formulation demonstrated good cytotoxicity profiles and stability, with no adverse effects observed in clinical trials on healthy volunteers. This suggests a promising natural approach for treating acne and reducing skin inflammation, warranting further research for pharmaceutical and cosmeceutical applications.
34 citations
,
October 2024 in “Clinical Cosmetic and Investigational Dermatology” Azelaic acid is effective for treating rosacea, acne, and melasma.
July 2023 in “Dermatology and Therapy” 5-Alpha Reductase Inhibitors are effective for male hair loss and some skin conditions, but their effectiveness in women and safety concerns require careful use.
7 citations
,
December 2019 in “American Journal of Clinical Dermatology” Topical therapies show promise for hair loss and acne treatment with minimal side effects.
187 citations
,
January 1994 in “The New England Journal of Medicine” Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.
4 citations
,
January 2008 in “Food Science and Technology Research” Mature leaves of 'Saijo' persimmon have the most vitamin C and both mature leaves and new shoots are rich in polyphenols.
January 2025 in “International Journal of Biological Innovations” Medicinal plant substances can help prevent hair loss and improve hair health.
27 citations
,
April 2023 in “Pharmaceuticals” Ziziphus lotus is a safe plant with potential health benefits, but more research is needed.
7 citations
,
December 2021 in “Pharmaceutics” Natural products like plant extracts can help promote hair growth and could be used to treat hair loss.
39 citations
,
June 2017 in “Journal of Applied Research on Medicinal and Aromatic Plants” Plant-based ingredients are effective and safe for modern skincare products.
