Skin Aging And Barrier Dysfunction: Bridging Current Therapies With Future Genetic And Nanotechnological Interventions

Genetic cosmeceuticals utilizing nanotechnology represent a promising advancement in personalized anti-aging skincare by enabling precise delivery of genetic elements like SIRT1 and FOXO3 to skin cells, crucial for reducing cellular senescence and enhancing skin regeneration. Nanocarriers such as lipid nanoparticles, polymeric nanoparticles, and exosomes protect these genetic elements from degradation and ensure targeted delivery to dermal fibroblasts and keratinocytes, minimizing off-target effects. This review highlights the potential of these nano-formulations to synergistically reduce oxidative stress and improve skin health when combined with growth factors and antioxidants, marking a significant shift towards targeted, minimally invasive, and customized anti-aging therapies.