Cellular Senescence in Skin-Related Research: Targeted Signaling Pathways and Naturally Occurring Therapeutic Agents

The review examines the dual role of cellular senescence in skin aging, noting its contribution to both beneficial and detrimental effects. Cellular senescence, characterized by irreversible cell cycle arrest, is influenced by factors like UV radiation and leads to the accumulation of senescent cells, such as fibroblasts and melanocytes, which contribute to aging through inflammatory secretions and extracellular matrix degradation. The document highlights the potential of targeting senescence pathways with senolytic and senomorphic agents, including plant-derived compounds, to develop therapies for skin aging and related disorders. It also discusses the impact of senescence on hair disorders like androgenetic alopecia, emphasizing the potential of senolytics like FOXO4-DRI and plant-derived compounds to reduce hair loss and promote skin rejuvenation. The review underscores the need for further research on the bioavailability and delivery systems of these compounds for effective skin therapies.