Spanlastic Nano-Vesicles: A Novel Approach to Improve the Dissolution, Bioavailability, and Pharmacokinetic Behavior of Famotidine

The study investigates the use of spanlastic nano-vesicles (SNVs) to improve the dissolution, bioavailability, and pharmacokinetic behavior of famotidine (FMT), a drug with poor solubility and permeability. By optimizing the formulation with surfactants like Span 60 and Tween 60, the researchers achieved a formulation with small particle size, high entrapment efficiency, and improved drug loading. The SNVs demonstrated a biphasic drug release pattern, enhancing the maximum plasma concentration (Cmax) and area under the curve (AUC0–24) compared to FMT suspension, indicating improved bioavailability and absorption. The study highlights the potential of SNVs to overcome challenges in delivering BCS class IV drugs like FMT, though further research on safety and scalability is needed.