Spanlastics: An Innovative Nanovesicular Platform for Advanced Drug Delivery

Spanlastics are an innovative drug delivery system designed to address the limitations of traditional formulations like liposomes and nanoparticles, particularly for drugs with low solubility and bioavailability. These elastic, non-toxic vesicles can entrap drugs within their core, offering controlled and targeted delivery, which enhances the bioavailability of poorly soluble drugs and provides improved stability. Spanlastics are effective in delivering both hydrophilic and lipophilic drugs to specific sites, thereby reducing side effects and improving therapeutic outcomes. The review discusses the classification, preparation methods, mechanisms, evaluation techniques, and diverse applications of spanlastics in modern drug delivery.