Design, Development, and Optimization of Spanlastics for Delivery of Rizatriptan Benzoate

The study focused on developing and optimizing spanlastics, a nanovesicular drug delivery system, for delivering Rizatriptan Benzoate. Using Box-Behnken and response surface central composite designs, the researchers optimized the formulation by adjusting Span 60, cremophor EL 40, and sonication time to achieve a small particle size (84.98 nm), low polydispersity index (0.1993), and high entrapment efficiency (53.69%). The optimized spanlastic formulation demonstrated an 88.5% drug release over 8 hours and showed compatibility with excipients. The drug existed in an amorphous state within the nearly spherical vesicles, indicating that spanlastics are effective carriers for drug delivery.