Spatiotemporal Dynamics of Mammalian Wound Healing

The document discusses the concept of spatiotemporal clocks as a framework for understanding the coordination of phases in mammalian wound healing, which includes hemostasis, inflammation, proliferation, and remodeling. It emphasizes the roles of different spatial domains such as the epidermis, dermis, fascia, wound edges, and wound center, and the oscillatory molecular signals that regulate their interactions. The study highlights wound-induced hair neogenesis (WIHN) as a model for regenerative potential. By integrating spatial and temporal dimensions, this framework aims to unify the complex aspects of wound healing and support the development of new therapeutic strategies.