Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy

The study explores the use of spermine lipid-assembled nanoparticles for delivering small-interference RNAs (siRNA) targeting the androgen receptor (AR) as a therapy for androgenetic alopecia (AGA). Researchers synthesized spermine-derived ionizable lipids with varying alkyl chains and formulated them into Sper-N/siRNA lipid nanoparticles. In vitro experiments showed that Sper-12-based nanoparticles effectively delivered siRNA for AR gene silencing. In vivo studies on AGA model mice demonstrated that intradermal administration of Sper-12/siAR nanoparticles suppressed aberrant AR protein, promoted hair follicle proliferation, and alleviated hair loss symptoms. This suggests that Sper-12/siRNA nanoparticles could be a promising platform for siRNA-based AGA treatments.