Sprayable Supramolecular Hydrogel with Minimalism for Wilderness First Aid: Integration of Mechanical Performance and Biofunctionality

The study introduces a sprayable supramolecular hydrogel (FPC hydrogel) for wilderness first aid, highlighting its mechanical performance and biofunctionality. Composed of FA, PDRN, and COL-III, the hydrogel offers significant anti-inflammatory and angiogenic benefits, promoting wound healing through granulation tissue formation, collagen deposition, and epithelialization. It is notable for its sprayability, tissue adhesiveness, and biological performance, making it suitable for emergency wound management. The hydrogel can be sterilized by boiling and retains its properties after storage. It shows antibacterial activity against E. coli and S. aureus, enhances fibroblast proliferation and migration, supports angiogenesis, and reduces inflammation. In a diabetic mouse model, it accelerated wound closure and improved tissue repair quality, including epidermal regeneration and nascent hair follicle formation.