Taurine-Based Active Pharmaceutical Ingredient Ionic Liquids Modulate the Perifollicular Microenvironment for Androgenic Alopecia Treatment

This study introduces a taurine-based active pharmaceutical ingredient ionic liquid (CTIL) as a novel treatment for androgenic alopecia (AGA). CTIL is synthesized through a one-step method and functions both as a delivery carrier and a therapeutic agent. It effectively penetrates the skin barrier, targeting hair follicles to deliver antioxidants and modulate the perifollicular microenvironment by scavenging reactive oxygen species (ROS). In vitro studies show that CTIL's hydrogen-bond network structure enhances its penetration and accumulation in hair follicles. In an AGA animal model, CTIL reduced ROS, alleviated oxidative damage and inflammation, inhibited hair follicle miniaturization, and promoted hair regrowth. This research highlights the potential of bioactive ionic liquids in treating AGA by integrating delivery and therapeutic functions.