THE INFLUENCE OF SKIN MICROBIOME IMBALANCE ON SPECIFIC PATHOLOGICAL SKIN CONDITIONS

December 2025 in “ International Journal of Innovative Technologies in Social Science ”

Michał Wycik, Hubert Chmielewski, Julia Komar, Artur Wądołowski, Gabriela Kondratiuk, Ada Kondrat, Michał Szczupak, Paweł Mierzejewski, Justyna Werno, Zuzanna Twarowska

TLDR Imbalanced skin microbiome can worsen skin conditions like acne and eczema.

The study highlights the significant impact of skin microbiome imbalance, or dysbiosis, on various skin conditions, including atopic dermatitis, psoriasis, acne, rosacea, skin cancer, and impaired wound healing. Dysbiosis, driven by genetic, environmental, and therapeutic factors, disrupts barrier function and causes chronic inflammation. In atopic dermatitis and psoriasis, it leads to immune dysregulation due to pathogenic overgrowth and reduced microbial diversity. Acne and rosacea are linked to specific bacterial changes that promote inflammation. The skin microbiome also affects skin cancer progression and wound healing. Understanding these interactions may enable precision medicine approaches to enhance skin health and treat related diseases.

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research The Microbiome in Patients with Atopic Dermatitis

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People with atopic dermatitis have different skin bacteria, and targeting these bacteria might help treat the condition.

THE INFLUENCE OF SKIN MICROBIOME IMBALANCE ON SPECIFIC PATHOLOGICAL SKIN CONDITIONS

Research cited in this study

research The Role of the Skin Microbiome in Wound Healing

research The Skin Microbiome: Current Landscape and Future Opportunities

research Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism

research The Wound Microbiome

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research Acne, the Skin Microbiome, and Antibiotic Treatment

research The Microbiome in Patients with Atopic Dermatitis