The Role of <scp>dWAT</scp> ‐Immune Crosstalk in Hair Follicle Microenvironment in Hair Regeneration

August 2026 in “ The Journal of Dermatology ”

Rongtian Ye, Xiuzu Song

TLDR dWAT actively supports hair growth by interacting with immune cells.

This review highlights the critical role of dermal white adipose tissue (dWAT) in the hair follicle microenvironment, emphasizing its active participation in hair regeneration. dWAT is not merely a passive structure but engages in complex interactions with local immune cells through cytokines, metabolites, extracellular vesicles, and cell-cell interactions. These interactions are crucial for maintaining immune homeostasis, regulating inflammation, and supporting hair growth. The dynamic remodeling of dWAT during the hair follicle cycle provides essential metabolic support and facilitates immune cell communication, influencing hair follicle regeneration by modulating local inflammatory responses and immune cell behavior.

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