Journal Club: Recent Therapeutic Developments in Trichology

May 2022 in “ European Journal of Dermatology ”

Inmaculada Balaguer‐Franch, Enrique Rodríguez‐Lomba, M. Lefèvre, Sophia Mohme, Neda Alband, Miguel Nogueira, Ángel Manuel Rosell‐Díaz

androgenetic alopecia hair follicle miniaturization testosterone dihydrotestosterone type II 5α-reductase finasteride minoxidil AGA DHT Propecia Rogaine

TLDR New treatments for hair loss are being developed.

The document discussed recent therapeutic developments in trichology, focusing on androgenetic alopecia (AGA), which affected more than half of men below 50 years of age. AGA was characterized by hair follicle miniaturization due to increased conversion of testosterone to dihydrotestosterone (DHT) by type II 5α-reductase. Traditional treatments included oral finasteride and topical minoxidil. The paper likely explored advancements beyond these common treatments, although specific new therapies were not detailed in the provided text.

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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