Therapeutic Potential of Polydeoxyribonucleotide (PDRN) in Dermatology and Aesthetic Medicine: Molecular Mechanisms and Anti-Aging Applications

Polydeoxyribonucleotide (PDRN), derived from salmon sperm DNA, shows promise in dermatology and aesthetic medicine due to its regenerative, anti-inflammatory, and antioxidant properties. It works by activating adenosine A2A receptors and other pathways, promoting collagen synthesis, fibroblast proliferation, angiogenesis, DNA repair, and inflammation modulation. Evidence supports its effectiveness in improving skin elasticity, reducing wrinkles and acne scars, enhancing wound healing, stimulating hair growth, and alleviating hyperpigmentation. Despite its safety and biocompatibility, further research is needed to establish standardized protocols and assess long-term outcomes, highlighting PDRN's potential as a valuable tool in skin rejuvenation.