The Use of Tofacitinib in the Treatment of Immune-Mediated Universal Alopecia in a Patient with Systemic Lupus Erythematosus: A Case Report

    January 2021 in “ Anais do Congresso Brasileiro de Reumatologia 2020 ”
    Sanna Paula Pires Mariano Campos, Danielle Christinne Soares Egypto de Brito, Thyago Talles de Almeida Santana, Daniel Freire de Medeiros, Ana Karla Guedes de Melo, Eutília Andrade Medeiros Freire
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    TLDR Tofacitinib improved arthritis and partially improved hair loss in a lupus patient without side effects.
    In a case report from 2021, a 31-year-old female patient with systemic lupus erythematosus (SLE) who had been suffering from the disease for six years developed universal alopecia and an exacerbation of polyarthritis that was unresponsive to standard treatments. The patient began treatment with 5 mg of tofacitinib twice daily alongside hydroxychloroquine, which led to a total improvement in arthritis and a partial improvement in alopecia within four months. Significant hair regrowth was observed in the eyebrows, eyelashes, axillary, and pubic areas. No adverse events related to tofacitinib were reported. The case suggests that targeting Janus kinase (JAK) with tofacitinib is a promising therapeutic approach for SLE and immune-mediated universal alopecia, demonstrating rapid action and a good safety profile. However, the report calls for more extensive studies to confirm these results.
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      in Treatment 2 months ago
      The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 10 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

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      in Treatment  2 upvotes 6 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

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      in Product  1 upvotes 6 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       7 upvotes 9 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

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