Current Trends And Novel Approaches In Platelet-Rich Plasma Therapy: A Comprehensive Review

    May 2026 in “ International Journal of Drug Delivery Technology ”
    Rajendran Akash, Sathiyamoorthy Rajesh, Sarkgunan Sedhu Raagavan, Mohammed Wasiq Rahman M, Hemamalini Kannan, Priya Dharshini Govindaraj, Someswaran R K, Nandhini R, Dharshini S, Bhuvaragavan Devi Shree
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    TLDR PRP therapy shows promise for tissue repair but needs personalized approaches and faces challenges like quality variability and side effects.
    This comprehensive review discusses the current trends and novel approaches in platelet-rich plasma (PRP) therapy, highlighting its therapeutic potential due to autologous growth factors for tissue repair and regeneration. PRP's applications span orthopedics, dermatology, dentistry, wound healing, and plastic surgery, with recent focus areas including osteoarthritis, hair restoration, and maxillofacial regeneration. Innovations involve combining PRP with biomaterials, stem cell therapy, and aesthetic medicine. The review emphasizes the need for individualized PRP therapy, addressing patient-specific concerns and optimizing dosing. Challenges include variability in PRP quality, regulatory issues, and potential side effects. Future directions involve genomic insights, nanotechnology, and regenerative medicine applications, aiming to address unmet needs and advance PRP's application.
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