Upcycled Postbiotic Cell-Free Supernatants from Limosilactobacillus Fermentum MG901 and MG4237 Alleviated Oxidative Stress-Induced Dysfunction in Human Follicle Dermal Papilla Cells

This study demonstrates that upcycled postbiotic cell-free supernatants (CFSs) from Limosilactobacillus fermentum MG901 and MG4237 can alleviate oxidative stress-induced dysfunction in human follicle dermal papilla cells, a key factor in hair loss. The CFSs showed no cytotoxicity and improved wound-healing capacity while reducing reactive oxygen species accumulation. They also restored mitochondrial function and increased dermal papilla cell-specific markers like alkaline phosphatase activity. The protective effects were linked to modulation of Wnt/β-catenin signaling and mitochondrial regulation. These results suggest that these CFSs could be used as sustainable cosmetic ingredients to help mitigate hair loss.