Whitaker syndrome: A case report of autoimmune polyendocrine syndrome type 1 with dilated cardiomyopathy

    September 2024 in “ Clinical Case Reports ”
    Gohar Ali, Bilal Ahmed, Shahroz Azhar, Aqsa Iqbal, Ali Usman, Muhammad Husnain Ahmad, Masab Ali, Muhammad Jawaid
    TLDR Early recognition and multidisciplinary management of Whitaker syndrome can improve patient outcomes.
    This case report discusses a 28-year-old male with autoimmune polyendocrine syndrome type 1 (APS-1), also known as Whitaker syndrome, characterized by mucocutaneous candidiasis, adrenal insufficiency, and hypoparathyroidism. The patient presented with symptoms including shortness of breath, pedal edema, alopecia, and oral candidiasis. Diagnostic tests revealed dilated cardiomyopathy, pericardial effusion, and pleural effusion, alongside laboratory findings of hypocalcemia and hormonal imbalances. This case is notable as the first reported in Pakistan and the second worldwide with such a combination of symptoms, highlighting the importance of early recognition and multidisciplinary management to improve patient outcomes.
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