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GlossaryCancer-Associated Fibroblasts

specialized cells in tumors that support cancer growth and spread

Cancer-Associated Fibroblasts (CAFs) are specialized cells found within the tumor microenvironment that play a crucial role in cancer progression. They support tumor growth by remodeling the extracellular matrix, promoting angiogenesis (formation of new blood vessels), and secreting signaling molecules that enhance cancer cell survival and invasion.

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research Multi-omics analysis unveils the role of cancer-associated fibroblasts in cutaneous squamous cell carcinoma

November 2025 in “Cancer Cell International”

Cancer-associated fibroblasts promote tumor growth in skin cancer.

Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

research Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanoma

March 2024 in “Frontiers in genetics”

Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.

research 1376 A multi-scale spatial atlas of human skin links cancer cell states to site of origin

April 2023 in “Journal of Investigative Dermatology”

The research shows that skin cancer likely originates from hair follicles and that certain cell populations expand to promote skin cancer growth.

research Fibrotic enzymes modulate wound‐induced skin tumorigenesis

15 citations , March 2021 in “EMBO Reports”

PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.

research Multiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma

2 citations , January 2024 in “Proceedings of the National Academy of Sciences of the United States of America”

The research created a detailed map of skin cells, showing that certain cells in basal cell carcinoma may come from hair follicles and could help the cancer grow.

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community The most nuclear stack possible

in Satire 42 upvotes 1 year ago

A user humorously suggests an extreme hair loss treatment regimen involving multiple medications and therapies, including Dutasteride, Minoxidil, RU58841, and others, claiming it would prevent hair loss but with potential side effects like gynecomastia. The conversation highlights concerns about safety, side effects, and the effectiveness of such a comprehensive approach.

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in Chat 198 upvotes 10 months ago

Finasteride and minoxidil use resulted in a more youthful appearance and improved skin. There is debate about their effects on collagen and skin aging, with no solid evidence supporting significant changes due to finasteride.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 4 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.