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Glossaryp21 (CIP1)

protein that inhibits cell cycle progression for DNA repair

p21 is a protein that acts as a regulator of the cell cycle. It is known for its role in inhibiting the activity of cyclin-dependent kinases (CDKs), which are crucial for cell division. By doing so, p21 can halt the cell cycle, allowing for DNA repair or triggering cell death if the damage is irreparable. This function is particularly important in preventing the proliferation of damaged cells, which can lead to cancer.

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P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

research P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein p21 is more abundant in normal skin cells than in melanoma cells and may help protect against melanoma, with UVB light affecting its levels.